Acne Rosacea – Treatment Options

Oral doxycycline, tetracycline, isotretinoin, and topical metronidazole and ivermectin all options for acne rosacea Clinical Question: What are the most effective treatments for acne rosacea? Bottom Line: In addition to the old standbys (doxycycline, tetracycline, and topical metronidazole), other drugs that may be effective for acne rosacea include isotretinoin and topical ivermectin. Topical brimonidine reduces… Continue reading Acne Rosacea – Treatment Options

Nicotinamide for Skin Cancer Prevention

Background:  Oral nicotinamide (form of vitamin B3) mitigates some effects of UV radiation through decreasing ATP depletion and glycolytic blockade. Randomized, placebo-controlled trial of nicotinamide 500mg BID in patients at high risk (>= 2 nonmelanoma skin cancers in the past 5 years).  Incidence of all new NMSCs 23% lower in nicotinamide group compared to placebo… Continue reading Nicotinamide for Skin Cancer Prevention

TMP/SMX Improves Cure Rate After Incision and Drainage of Abscesses in High-MRSA Areas

Trim-sulfa improves cure rate for cutaneous skin abscess after incision and drainage Clinical Question: Does adding trimethoprim-sulfamethoxazole after incision and drainage of a superficial skin abscess improve cure rates? Bottom Line: For patients with a superficial skin abscess for which the likelihood of community-acquired methicillin-resistant Staphylococcus aureus (MRSA) is high, trimethoprim-sulfamethoxazole for 7 days increases cure rates (number needed to treat… Continue reading TMP/SMX Improves Cure Rate After Incision and Drainage of Abscesses in High-MRSA Areas

Skin Biopsy Not Useful in Diagnosis of Cellulitis

Clin Infect Dis 2015 Aug 3 Most culture results in cellulitis are negative, and most causes remain unidentified. Multicenter study of 30 adults with acute cellulitis (duration < 4 days, most lower extremity) without drainage, presenting to ED. None had received abx =< 72 hours prior to biopsy. All pts had punch biopsy from center… Continue reading Skin Biopsy Not Useful in Diagnosis of Cellulitis