New Statin Recommendations for Primary Prevention from USPSTF

USPSTF 2016 recommendations on statin use for primary prevention of CVD


Clinical Question:
What are the benefits and harms of statin treatment for dyslipidemia in adults 21 years and older?

Bottom Line:
The United States Preventive Services Task Force (USPSTF) now recommends that adults
without a history of cardiovascular disease (CVD) use a low- to moderate-dose statin for the primary prevention of CVD events when ALL THREE of the following criteria are met: The patient (1) is 40 to 75 years old; (2) has at least one CVD risk factor (ie, dyslipidemia, diabetes, hypertension, or smoking); and (3) has a calculated 10-year risk of a CVD event of 10% or greater (B recommendation). The USPSTF further concludes that statin use may be beneficial for the primary prevention of CVD events
in some adults aged 40 to 70 years with at least 1 CVD risk factor and a 10-year CVD event risk of 7.5% to 10%, although the likelihood of benefit is smaller (C recommendation). Finally, current evidence is insufficient to assess whether to initiate statin therapy for prevention of CVD events in adults 76 years or older (I statement). (LOE = 1a-)

Reference:
Bibbins-Domingo K; US Preventive Services Task Force. Statin use for the primary prevention of cardiovascular disease in adults. US Preventive Services Task Force recommendation statement. JAMA 2016;316(19):1997-2007.

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