Nicotinamide for Skin Cancer Prevention

Background:  Oral nicotinamide (form of vitamin B3) mitigates some effects of UV radiation through decreasing ATP depletion and glycolytic blockade.
Randomized, placebo-controlled trial of nicotinamide 500mg BID in patients at high risk (>= 2 nonmelanoma skin cancers in the past 5 years).  Incidence of all new NMSCs 23% lower in nicotinamide group compared to placebo at 12 mos.  Individual rates of SCC, BCC and AK also lower in nicotinamide group.  Effect ended with end of therapy.
Conclusion:  this could be a safe, low-side-effect option for skin cancer prevention.
N Engl J Med 2015 Oct 22; 373:1618.

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