Does adding trimethoprim-sulfamethoxazole after incision and drainage of a superficial skin abscess improve cure rates?
For patients with a superficial skin abscess for which the likelihood of community-acquired methicillin-resistant Staphylococcus aureus (MRSA) is high, trimethoprim-sulfamethoxazole for 7 days increases cure rates (number needed to treat [NNT] = 14), reduces the likelihood of requiring additional drainage (NNT = 20), and reduces the
likelihood of skin infections in household members (NNT = 42). Harms were
limited to nonserious gastrointestinal symptoms. (LOE = 1b)
Talan DA, Mower WR, Krishnadasan A, et al. Trimethoprim-sulfamethoxazole
versus placebo for uncomplicated skin abscess. N Engl J Med 2016;374(9):823-832.