CBT similar to second-generation antidepressants for major depressive disorder
Is cognitive behavioral therapy as effective as second-generation antidepressant treatment for patients with major depressive disorder?
The research is depressingly poor when it comes to answering this question. The available research shows equal benefit with drug therapy or talk therapy in terms of inducing a response or remission. There is no research on whether relapse is prevented
more by one approach or the other. None of the studies in this systematic
review included a no-treatment group, so we also don’t know whether either
treatment was better than doing nothing. (LOE = 1a-)
Amick HR, Gartlehner G, Gaynes BN, et al. Comparative benefits and harms of
second generation antidepressants and cognitive behavioral therapies in
initial treatment of major depressive disorder: systematic review and
meta-analysis. BMJ 2015;351:h6019.