Do hyaluronic acid injections in patients with knee degenerative joint disease improve pain and function?
The highest quality studies, which are now fairly plentiful, show that hyaluronic acid
injections are only minimally better than sham injections in improving pain and function in patients with knee degenerative joint disease. (LOE = 1a-)
Jevsevar D, Donnelly P, Brown GA, Cummins DS. Viscosupplementation for osteoarthritis of the knee. J Bone Joint Surg Am