ASCVD Calculator Overestimates Risk in Real-World Cohort

CVD risk calculator overestimates risk

Clinical Question:

Does the American College of Cardiology/American Heart Association Pooled Cohort Risk equation accurately predict cardiovascular risk in a typical cohort of patients?

Bottom Line:

This risk calculator substantially overestimatesthe actual occurrence of atherosclerotic cardiovascular disease (ASCVD) events over 5 years in a typical multiethnic population. The riskcalculator estimates 10-year risk, but the authors extrapolated the
equation to 5 years and compared the results since the risk increase seems to be linear. As has been pointed out before, this frequently used risk calculator substantially overestimates the percentage of patients who will benefit from lipid-lowering treatment. (LOE = 1b)
Rana JS,
Tabada GH, Solomon MD, et al. Accuracy of the atherosclerotic
cardiovascular risk equation in a large contemporary, multiethnic
population. J Am Coll Cardiol 2016;6(18):2118-2130.

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