Three meta-analyses and five clinical practice guidelines addressing whether fasting was necessary to measure accurately or predict CV events.
Nonfasting test results result in clinically-insignificant changes compared with fasting for TC, HDL and LDL
Only modest changes in TG levels
Non-fasting = fasting for prediction of adverse CVD events
Non-fasting sometimes STRONGLY predictive (because this is how people live)
Clinical practice guidelines now recommend non-fasting
If TG > 400, get a fasting panel (European Guidelines) – only 10% needed this.
Conclusion: Don’t get fasting lipid panels anymore!
JAMA Intern Med 2016 Apr 27