Systemic Causes of Pruritis – Differential Diagnosis

Pruritis – Systemic DDx

Autoimmune
   Dermatitis herpetiformis,
   dermatomyositis, Sjogren
   syndrome
Hematologic
   Hemochromatosis, Fe-def anemia,
   Mastocytosis, plasma call
   dyscrasia, PV
Hepatobiliary
   PBC, chronic pancreatitis,
   cholestasis, hepatitis C, sclerosing
   cholangiitis
Infectious
   AIDS, hepatitis, parasites
  (Giardia, onchocerciasis,
   schistosomiasis, ascariasis)
Malignant
   Leukemia, lymphoma, MM,
   paraneoplastic syndrome
Metabolic/Endocrine
   Carcinoid, CRF, DM,
   hyper/hypothyroidism, hyperPTH
Neurologic
   Cerebral abscess, tumor, MS,
   stroke
Other
   Drug ingestion, eating disorders,
   neuropsychiatric d/o, pregnancy
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