Proton Pump Inhibitors – Risks of Long-Term Use

Our current list of adverse effects and risks of long-term PPI use:

  • Hypomagnesemia
  • Fractures of the hip, wrist and spine
  • Community-acquired pneumonia
  • C diff and other enteric infections
  • Cardiac events with given with clopidogrel
  • Possibly interfering with B12, folate, iron absorption
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