Proteinuria – Differential Diagnosis

Proteinuria DDx – Glomerular, Tubular and Overflow

Glomerular
  Primary
    Minimal change
    Idiopathic membranous GN
    Focal segmental GN
    Membranoproliferative GN
    IgA nephropathy
  Secondary
     DM
     Collagen vascular dz (lupus)
     Amyloidosis
     Preeclampsia
     Infx (HIV, hep B and C, PSGN,
        syphilis, malaria, endocarditis)
     GI and lung CA
     Lymphoma, chronic renal
        transplant rejection
  Drugs
     Heroin, NSAIDs, gold,
     penicillamine, Li, heavy metals
Tubular
   Hypertensive nephrosclerosis
   Tubulointerstitial dz due to:
      Uric acid nephropathy
      Acute hypersensitivity interstitial
          nephritis
      Fanconi syndrome
      Heavy metals
      Sickle cell dz
      NSAIDs, antibiotics
Overflow
   Hemoglobinuria
   Myoglobinuria
   Multiple myeloma
   Amyloidosis
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