A shorter course of antibiotics based on clinical stability is safe and
effective for CAP
Are shorter courses of antibiotics
based on clinical criteria effective in treating patients with
As recommended by guidelines
from the Infectious Diseases Society of America (IDSA) and the American
Thoracic Society (ATS), a minimum of 5 days of antibiotic therapy with
discontinuation of antibiotics based on clinical stability is an
appropriate strategy for the treatment of community-acquired pneumonia
(CAP). (LOE = 1b)
Uranga A, Espana PP, Bilbao A, et al.
Duration of antibiotic treatment in community-acquired pneumonia. JAMA
Intern Med 2016 Jul 25. doi: 10.1001/jamainternmed.2016.363
What is the best antibiotic strategy to improve
outcomes in patients hospitalized with community-acquired pneumonia?
For patients hospitalized with community-acquired pneumonia
(CAP), start antibiotics early, use either fluoroquinolone monotherapy or
beta-lactam/macrolide combination therapy, and switch to oral antibiotics
as soon as patients are hemodynamically stable and can take oral
medications. Although the evidence is mostly of low quality, this review
reaffirms what we already do. (LOE = 2a)
Lee JS, Giesler DL,
Gellad WF, Fine MJ. Antibiotic therapy for adults hospitalized with
community-acquired pneumonia. JAMA 2016;315(6):593-602.