Suppressive HIV Treatment Reduces Transmission in Serodifferent Couples

Suppressive treatment results in zero HIV transmission in serodifferent
couples reporting condomless sex

Clinical Question:
Is the use of
suppressive antiretroviral therapy associated with low HIV transmission
rates to HIV-seronegative partners during condomless sex?

Bottom Line:
In this study of serodifferent couples with the HIV-positive partner using
continuous antiretroviral therapy (ART) and reporting regular condomless
sex, no documented cases of within-couple HIV transmission occurred during
a median follow-up of 1.3 years per couple. This included both heterosexual
couples and men having sex with men (MSM). The study is ongoing for the
cohort of MSM and further results are forthcoming. (LOE = 1b)

Rodger AJ, Cambiano V, Bruun T, et al, for the PARTNER Study Group. Sexual
activity without condoms and risk of HIV transmission in serodifferent
couples when the HIV-positive partner is using suppressive antiretroviral

therapy. JAMA 2016;316(2):171-181.

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