Procalcitonin as a Guide to Stopping Antibiotics in the ICU

Procalcitonin guidance safely decreases antibiotic use in critically ill
patients

Clinical Question:

Can the use of procalcitonin levels to determine when to discontinue antibiotic therapy safely reduce the duration of antibiotic use in critically ill patients?

Bottom Line:

For patients in the intensive care unit (ICU) who receive antibiotics for presumed or
proven bacterial infections, the use of procalcitonin levels to determine when to stop antibiotic therapy results in decreased duration and consumption of antibiotics without increasing mortality. (LOE = 1b)
Reference:
De Jong E, Van Oers JA, Beishuizen A, et al. Efficacy and safety of procalcitonin guidance in reducing the duration of antibiotic treatment in critically ill patients: a randomised, controlled, open-label trial. Lancet Infect Dis 2016;16(7):819-827.
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