Low-Molecular-Weight Heparin Lower Risk for Heparin-Induced Thrombocytopenia than Unfractionated Heparin

Risk for HIT is approximately 5- to 10-fold lower with LMWH vs UFH.
10 year study in Canada of LMWH vs UFH to see if LMWH lowered risk of HIT and HIT with thrombosis.
Annual incidence of HIT decreased from 10.7 to 2.2 / 10,000 admissions; HIT with thrombosis decreased 4.6 to 0.4 / 10,000 admissions.
Avoiding UFH lowered risk of HIT care by 83% per year.
Blood 2016 April 21; 127:1954

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