Gabapentin-like Meds Ineffective for Pain After Knee Arthroplasty

Gabapentinoids not useful as adjunct pain management after knee

Clinical Question:
Are gabapentinoids useful in managing postoperative pain in patients undergoing total knee arthroplasty?

Bottom Line:
The gabapentinoids [gabapentin (Neurontin) and pregabalin (Lyrica)] are not significantly effective as an adjunct to pain management after total knee arthroplasty. (LOE = 1a-)

Hamilton TW,
Strickland LH, Pandit HG. A meta-analysis on the use of gabapentinoids for
the treatment of acute postoperative pain following total knee
arthroplasty. J Bone Joint Surg Am 2016;98(16):1340-1350.


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