Fluoroquinolones Slightly Increase Risk of Retinal Detachment

Studies conflict about FQ and retinal detachment risk.
French study of n = 28,000 patients undergoing retinal detachment surgery over 3 years.
Case-crossover design:  FQ use in 10 d prior to surgery vs control period (61-180 d prior to surgery).
AOR 1.5 for retinal detachment in those who recently used FQ
only individual FQ associated with this risk was levofloxacin
RR was increased, but AR increase was tiny – only 1 in 1000 retinal detachment patients had FQ exposure.
JAMA Ophthalmol 2016 April; 134:415

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