Calorie Restriction in Non-Obese Adults Makes Life Better

n = 220 non-obese adults (mean age 38, mean BMI 25) randomized to 2 years of 25% CR vs usual intake (ad lib).  CR participants received group and individual counseling throughout.
At 2 years:
 – mean weight loss 7.6 kg in CR group (10%) vs 0.4 kg in control
 – CR group had significant improvements in mood, QOL, sleep, sexual drive and relationship satisfaction.
 – most improvements in CR group correlated with wt loss
JAMA Intern Med 2016 May 2

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