ASA for Primary Prevention: USPSTF 2016

Who benefits from ASA for pirmary prevention of CVD and colorectal cancer:

  • Ages 50-59 who:
    • At least 10% ASCVD risk and
    • Without risk factors for major bleeding and
    • Willingness to take ASA for at least 10 years
  • Ages 60-69:
    • C recommendation – selectively offer based on risk and benefits
  • Ages 70
    • insufficient evidence (level I)


USPSTF: Some adults should take aspirin to prevent CVD, colorectal cancer
Clinical Question:
Should adults take aspirin to lower the risk of cardiovascular disease and colorectal cancer?

Bottom Line:
The U.S. Preventive Services Task Force (USPSTF) recommends that adults aged 50
years to 59 years take 81 mg aspirin per day to prevent both cardiovascular
disease (CVD) and colorectal cancer if they meet the following criteria: (1) 10% or greater CVD risk, (2) no increased risk for bleeding, (3) a life expectancy of at least 10 years, and (4) a willingness to continue treatment for at least 10 years. This is a B recommendation (should be offered to individuals meeting the criteria). (LOE = 5)


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